#IFEStandardized nameMoleculeOrganismSourceRfamTitleMethodRes. ÅDate
18H6L|1|5A (rep)U5 spliceosomal RNApre-mRNA, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of human exon-defined spliceosome in the early B state.Electron microscopy2.62024-05-01
28H6K|1|5AU5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of human exon-defined spliceosome in the mature B state.Electron microscopy2.72024-05-01
38C6J|1|5U5 spliceosomal RNAPM5 5' Exon, U5 snRNAHomo sapiensEukaryaRF00020Human spliceosomal PM5 C* complexElectron microscopy2.82023-07-12
46QW6|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution.Electron microscopy2.922019-04-17
57DVQ|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)Electron microscopy2.892021-03-31
67QTT|1|eU5 spliceosomal RNAMINX, U5 snRNAHomo sapiensEukaryaRF00020Structural organization of a late activated human spliceosome (Baqr, core region)Electron microscopy3.12023-05-10
78QPE|1|5U5 spliceosomal RNAoligo1, oligo2, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of Pre-B-like Complex (core part)Electron microscopy3.12024-05-22
88Q7N|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)Electron microscopy3.12024-01-24
98H6E|1|5AU5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.Electron microscopy3.22024-05-01
108H6J|1|5AU5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.Electron microscopy3.252024-05-01
118Q7Q|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2)Electron microscopy3.22024-04-17
128Q91|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the human 20S U5 snRNP coreElectron microscopy3.12024-03-27
136QX9|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).Electron microscopy3.282019-04-17
148RC0|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the human 20S U5 snRNPElectron microscopy3.22024-03-27
158QOZ|1|5U5 spliceosomal RNA5'ss RNA oligo, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part)Electron microscopy3.12024-05-22
166QDV|1|5U5 spliceosomal RNALigated exons: MINX mRNA, U5 snRNAHomo sapiensEukaryaRF00020Human post-catalytic P complex spliceosomeElectron microscopy3.32019-02-20
176ZYM|1|5U5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Human C Complex Spliceosome - High-resolution COREElectron microscopy3.42020-10-14
188Y6O|1|BU5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP partElectron microscopy3.382024-03-20
196ICZ|1|BU5 spliceosomal RNApre-mRNA, U5snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstromElectron microscopy32019-03-13
207W59|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020The cryo-EM structure of human pre-C*-I complexElectron microscopy3.62022-06-22
217W5A|1|BU5 spliceosomal RNAPre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020The cryo-EM structure of human pre-C*-II complexElectron microscopy3.62022-06-22
228QP8|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of Pre-B Complex (core part)Electron microscopy3.52024-05-22
236FF4|1|5U5 spliceosomal RNApre mRNA, U2 snRNA, U5 snRNAHomo sapiensEukaryaRF00020human Bact spliceosome core structureElectron microscopy3.42018-08-29
248Q7V|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1)Electron microscopy3.82024-04-17
258QPA|1|5U5 spliceosomal RNA5'ss oligo, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part)Electron microscopy3.72024-05-22
268QPB|1|5U5 spliceosomal RNA5'ss oligo, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of Pre-B+ATP Complex (core part)Electron microscopy3.72024-05-22
276ID0|1|BU5 spliceosomal RNAU5snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolutionElectron microscopy2.92019-03-13
285XJC|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstromElectron microscopy3.62017-07-05
298Q7W|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3)Electron microscopy3.92024-04-17
308QZS|1|5U5 spliceosomal RNAOligo 1, Oligo 2, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the cross-exon B-like complexElectron microscopy4.12024-05-22
316ID1|1|BU5 spliceosomal RNAU5snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolutionElectron microscopy2.862019-03-13
328QP9|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of Pre-B+AMPPNP Complex (core part)Electron microscopy4.12024-05-22
338R09|1|5U5 spliceosomal RNA5'ss oligo, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complexElectron microscopy4.32024-05-22
347W5B|1|BU5 spliceosomal RNAPre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020The cryo-EM structure of human C* complexElectron microscopy4.32022-06-22
357AAV|1|5U5 spliceosomal RNAMINX M3 pre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Human pre-Bact-2 spliceosome core structureElectron microscopy4.22020-12-09
368R0B|1|5U5 spliceosomal RNA5'ss oligo, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the cross-exon pre-B+ATP complexElectron microscopy4.42024-05-22
375YZG|1|BU5 spliceosomal RNAPre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolutionElectron microscopy4.12018-08-08
388QPK|1|5U5 spliceosomal RNA5'ss oligo, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of Pre-B+5'ss Complex (core part)Electron microscopy4.22024-05-22
396AHD|1|BU5 spliceosomal RNApre-mRNA, U5snRNAHomo sapiensEukaryaRF00020The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolutionElectron microscopy3.82018-11-14
405O9Z|1|5U5 spliceosomal RNAHomo sapiens U5 A small nuclear RNA, MINX pre-mRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex)Electron microscopy4.52017-08-16
418Q7X|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4)Electron microscopy4.62024-04-17
426FF7|1|5U5 spliceosomal RNApre-mRNA, U2 snRNA, U5 snRNAHomo sapiensEukaryaRF00020human Bact spliceosome core structureElectron microscopy4.52019-03-13
437ABF|1|5U5 spliceosomal RNAMINX M3 RNA, U5 small nuclear RNAHomo sapiensEukaryaRF00020Human pre-Bact-1 spliceosome core structureElectron microscopy3.92020-12-09
448QO9|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a human spliceosomal B complex protomerElectron microscopy5.292024-01-24
455Z58|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.Electron microscopy4.92018-09-19
467A5P|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Human C Complex Spliceosome - Medium-resolution PERIPHERYElectron microscopy52020-10-14
475Z56|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.Electron microscopy5.12018-09-19
488R0A|1|5U5 spliceosomal RNA5'ss oligo, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the cross-exon pre-B+5'ss complexElectron microscopy5.82024-05-22
498CH6|1|eU5 spliceosomal RNAMINX-M3, RNU5A-1Homo sapiensEukaryaRF00020Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).Electron microscopy5.92023-05-10
506AH0|1|BU5 spliceosomal RNAU5snRNAHomo sapiensEukaryaRF00020The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex)Electron microscopy5.72018-11-14
515MQF|1|5U5 spliceosomal RNAHomo sapiens U5 A small nuclear RNA, MINX pre-mRNA (intron)Homo sapiensEukaryaRF00020Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex)Electron microscopy5.92017-03-22
528R08|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the cross-exon pre-B+AMPPNP complexElectron microscopy6.12024-05-22
538RM5|1|5U5 spliceosomal RNA5'SS oligo, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complexElectron microscopy6.92024-05-22
545Z57|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstromElectron microscopy6.52018-09-19
553JCR|1|HU5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF000203D structure determination of the human*U4/U6.U5* tri-snRNP complexElectron microscopy72016-03-09
567ABG|1|5U5 spliceosomal RNAMINX M3 pre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Human pre-Bact-1 spliceosomeElectron microscopy7.82020-12-23
577ABI|1|5U5 spliceosomal RNAMINX M3 pre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Human pre-Bact-2 spliceosomeElectron microscopy82021-02-10
588QXD|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the cross-exon pre-B complexElectron microscopy9.62024-05-22

Release history

Release3.3363.3373.3383.3393.3403.3413.342
Date2024-05-222024-05-292024-06-052024-06-122024-06-192024-06-262024-07-03

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Instances are ordered to put similar structures near each other. Select one instance to see its 3D structure. Selecting two or more instances will show their superposition, but only chains with identical numbers of observed nucleotides will superpose well. Large structures are slow to display; this tool is not designed for that.

#SViewPDBTitleMethodResolutionLength
17A5P|1|5Human C Complex Spliceosome - Medium-resolution PERIPHERYELECTRON MICROSCOPY540
25MQF|1|5Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex)ELECTRON MICROSCOPY5.9114
35O9Z|1|5Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex)ELECTRON MICROSCOPY4.5114
46AH0|1|BThe Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex)ELECTRON MICROSCOPY5.7115
56AHD|1|BThe Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolutionELECTRON MICROSCOPY3.8115
68H6L|1|5ACryo-EM structure of human exon-defined spliceosome in the early B state.ELECTRON MICROSCOPY2.6115
78H6K|1|5ACryo-EM structure of human exon-defined spliceosome in the mature B state.ELECTRON MICROSCOPY2.7115
88R0A|1|5Cryo-EM structure of the cross-exon pre-B+5'ss complexELECTRON MICROSCOPY5.8115
98QPK|1|5Cryo-EM Structure of Pre-B+5'ss Complex (core part)ELECTRON MICROSCOPY4.277
108QPE|1|5Cryo-EM Structure of Pre-B-like Complex (core part)ELECTRON MICROSCOPY3.1115
118Q7N|1|5cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)ELECTRON MICROSCOPY3.1115
128QO9|1|5Cryo-EM structure of a human spliceosomal B complex protomerELECTRON MICROSCOPY5.29115
136ZYM|1|5Human C Complex Spliceosome - High-resolution COREELECTRON MICROSCOPY3.474
146FF4|1|5human Bact spliceosome core structureELECTRON MICROSCOPY3.470
156FF7|1|5human Bact spliceosome core structureELECTRON MICROSCOPY4.570
167AAV|1|5Human pre-Bact-2 spliceosome core structureELECTRON MICROSCOPY4.269
177ABI|1|5Human pre-Bact-2 spliceosomeELECTRON MICROSCOPY8114
187ABG|1|5Human pre-Bact-1 spliceosomeELECTRON MICROSCOPY7.8114
197ABF|1|5Human pre-Bact-1 spliceosome core structureELECTRON MICROSCOPY3.958
208H6E|1|5ACryo-EM structure of human exon-defined spliceosome in the late pre-B state.ELECTRON MICROSCOPY3.2114
218H6J|1|5ACryo-EM structure of human exon-defined spliceosome in the mature pre-B state.ELECTRON MICROSCOPY3.25114
228QP9|1|5Cryo-EM Structure of Pre-B+AMPPNP Complex (core part)ELECTRON MICROSCOPY4.171
238R08|1|5Cryo-EM structure of the cross-exon pre-B+AMPPNP complexELECTRON MICROSCOPY6.1104
246QW6|1|5Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution.ELECTRON MICROSCOPY2.92104
256QX9|1|5Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).ELECTRON MICROSCOPY3.28104
268QXD|1|5Cryo-EM structure of the cross-exon pre-B complexELECTRON MICROSCOPY9.6104
278QP8|1|5Cryo-EM Structure of Pre-B Complex (core part)ELECTRON MICROSCOPY3.571
288Q91|1|5Structure of the human 20S U5 snRNP coreELECTRON MICROSCOPY3.1104
298RC0|1|5Structure of the human 20S U5 snRNPELECTRON MICROSCOPY3.2104
308Q7W|1|5Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3)ELECTRON MICROSCOPY3.9104
318Q7X|1|5Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4)ELECTRON MICROSCOPY4.6104
328Q7V|1|5Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1)ELECTRON MICROSCOPY3.8104
338Q7Q|1|5Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2)ELECTRON MICROSCOPY3.2104
348Y6O|1|BCryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP partELECTRON MICROSCOPY3.38109
358QZS|1|5Cryo-EM structure of the cross-exon B-like complexELECTRON MICROSCOPY4.1109
368QPA|1|5Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part)ELECTRON MICROSCOPY3.779
378RM5|1|5Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complexELECTRON MICROSCOPY6.9112
388R0B|1|5Cryo-EM structure of the cross-exon pre-B+ATP complexELECTRON MICROSCOPY4.4112
398QPB|1|5Cryo-EM Structure of Pre-B+ATP Complex (core part)ELECTRON MICROSCOPY3.779
408R09|1|5Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complexELECTRON MICROSCOPY4.3112
418QOZ|1|5Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part)ELECTRON MICROSCOPY3.179
426QDV|1|5Human post-catalytic P complex spliceosomeELECTRON MICROSCOPY3.375
438C6J|1|5Human spliceosomal PM5 C* complexELECTRON MICROSCOPY2.8113
447DVQ|1|BCryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)ELECTRON MICROSCOPY2.8990
456ICZ|1|BCryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstromELECTRON MICROSCOPY397
466ID0|1|BCryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolutionELECTRON MICROSCOPY2.998
476ID1|1|BCryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolutionELECTRON MICROSCOPY2.8698
487W5B|1|BThe cryo-EM structure of human C* complexELECTRON MICROSCOPY4.384
497W5A|1|BThe cryo-EM structure of human pre-C*-II complexELECTRON MICROSCOPY3.684
507W59|1|BThe cryo-EM structure of human pre-C*-I complexELECTRON MICROSCOPY3.684
517QTT|1|eStructural organization of a late activated human spliceosome (Baqr, core region)ELECTRON MICROSCOPY3.198
528CH6|1|eStructure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).ELECTRON MICROSCOPY5.998
535XJC|1|BCryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstromELECTRON MICROSCOPY3.684
545YZG|1|BThe Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolutionELECTRON MICROSCOPY4.184
555Z56|1|Bcryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.ELECTRON MICROSCOPY5.184
565Z57|1|BCryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstromELECTRON MICROSCOPY6.584
575Z58|1|BCryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.ELECTRON MICROSCOPY4.984
583JCR|1|H3D structure determination of the human*U4/U6.U5* tri-snRNP complexELECTRON MICROSCOPY763

Heat map of mutual geometric discrepancy, in Angstroms per nucleotide. The ordering in the heat map is the same as in the table. The colorbar ranges from 0 to the maximum observed discrepancy. Click above the diagonal to select a range of structures, below the diagonal to select two structures.


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