Equivalence class NR_4.0_30925.2 Obsolete
| # | IFE | Standardized name | Molecule | Organism | Source | Rfam | Title | Method | Res. Å | Date |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4ZT0|1|D (rep) | single-guide RNA | Streptococcus pyogenes | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-ray diffraction | 2.9 | 2015-07-08 | |||
| 2 | 4ZT0|1|B | single-guide RNA | Streptococcus pyogenes | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-ray diffraction | 2.9 | 2015-07-08 | |||
| 3 | 4ZT9|1|D | single-guide RNA | Streptococcus pyogenes | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-ray diffraction | 3.1 | 2015-07-08 | |||
| 4 | 4ZT9|1|B | single-guide RNA | Streptococcus pyogenes | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-ray diffraction | 3.1 | 2015-07-08 | |||
| 5 | 7S4X|1|B | gRNA | synthetic construct | Cas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformation | Electron microscopy | 2.76 | 2022-03-02 | |||
| 6 | 6O0X|1|B | single guide RNA | synthetic construct | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | Electron microscopy | 3.28 | 2019-07-10 | |||
| 7 | 7S4V|1|B | gRNA | synthetic construct | Cas9 bound to 12-14MM DNA, 60 min time-point, kinked conformation | Electron microscopy | 3.28 | 2022-03-02 | |||
| 8 | 6O0Y|1|B | single guide RNA | synthetic construct | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | Electron microscopy | 3.37 | 2019-07-10 | |||
| 9 | 6O0Z|1|B | single guide RNA | synthetic construct | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | Electron microscopy | 3.3 | 2019-07-10 | |||
| 10 | 7S4U|1|B | gRNA | synthetic construct | Cryo-EM structure of Cas9 in complex with 12-14MM DNA substrate, 5 minute time-point | Electron microscopy | 3.56 | 2022-03-02 |
Release history
| Release | 3.220 | 3.221 | 3.222 | 3.223 | 3.224 | 3.225 | 3.226 | 3.227 | 3.228 | 3.229 | 3.230 | 3.231 | 3.232 | 3.233 | 3.234 | 3.235 | 3.236 | 3.237 | 3.238 | 3.239 | 3.240 | 3.241 | 3.242 | 3.243 | 3.244 | 3.245 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Date | 2022-03-02 | 2022-03-09 | 2022-03-16 | 2022-03-23 | 2022-03-30 | 2022-04-06 | 2022-04-13 | 2022-04-20 | 2022-04-27 | 2022-05-04 | 2022-05-11 | 2022-05-18 | 2022-05-25 | 2022-06-01 | 2022-06-08 | 2022-06-15 | 2022-06-22 | 2022-06-29 | 2022-07-06 | 2022-07-13 | 2022-07-20 | 2022-07-27 | 2022-08-03 | 2022-08-10 | 2022-08-17 | 2022-08-24 |
Parents
Children
| This class | Descendant classes | Release id | Intersection | Only in this class | Added to child |
|---|---|---|---|---|---|
| NR_4.0_30925.2 | NR_4.0_20965.1 | 3.246 | (10) 4ZT0|1|B, 4ZT0|1|D, 4ZT9|1|B, 4ZT9|1|D, 6O0X|1|B, 6O0Y|1|B, 6O0Z|1|B, 7S4U|1|B, 7S4V|1|B, 7S4X|1|B | (0) | (9) 7Z4C|1|A, 7Z4D|1|A, 7Z4D|1|F, 7Z4G|1|A, 7Z4H|1|A, 7Z4I|1|A, 7Z4J|1|A, 7Z4K|1|A, 7Z4L|1|A |
Instances are ordered to put similar structures near each other. Select one instance to see its 3D structure. Selecting two or more instances will show their superposition, but only chains with identical numbers of observed nucleotides will superpose well. Large structures are slow to display; this tool is not designed for that.
| #S | View | PDB | Title | Method | Resolution | Length |
|---|---|---|---|---|---|---|
| 1 | 4ZT9|1|D | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-RAY DIFFRACTION | 3.1 | 72 | |
| 2 | 4ZT0|1|D | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-RAY DIFFRACTION | 2.9 | 72 | |
| 3 | 4ZT0|1|B | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-RAY DIFFRACTION | 2.9 | 72 | |
| 4 | 4ZT9|1|B | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-RAY DIFFRACTION | 3.1 | 72 | |
| 5 | 6O0Y|1|B | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.37 | 98 | |
| 6 | 6O0X|1|B | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.28 | 98 | |
| 7 | 7S4V|1|B | Cas9 bound to 12-14MM DNA, 60 min time-point, kinked conformation | ELECTRON MICROSCOPY | 3.28 | 98 | |
| 8 | 7S4X|1|B | Cas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformation | ELECTRON MICROSCOPY | 2.76 | 98 | |
| 9 | 6O0Z|1|B | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.3 | 96 | |
| 10 | 7S4U|1|B | Cryo-EM structure of Cas9 in complex with 12-14MM DNA substrate, 5 minute time-point | ELECTRON MICROSCOPY | 3.56 | 97 |
Heat map of mutual geometric discrepancy, in Angstroms per nucleotide. The ordering in the heat map is the same as in the table. The colorbar ranges from 0 to the maximum observed discrepancy. Click above the diagonal to select a range of structures, below the diagonal to select two structures.
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