#IFEStandardized nameMoleculeOrganismSourceRfamTitleMethodRes. Å#NTsDate
14ZT0|1|D (rep)Trans-activating crRNAsingle-guide RNAStreptococcus pyogenesBacteriaRF02348Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolutionX-ray diffraction2.9722015-07-08
24ZT0|1|BTrans-activating crRNAsingle-guide RNAStreptococcus pyogenesBacteriaRF02348Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolutionX-ray diffraction2.9722015-07-08
34ZT9|1|DTrans-activating crRNAsingle-guide RNAStreptococcus pyogenesBacteriaRF02348Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolutionX-ray diffraction3.1722015-07-08
44ZT9|1|BTrans-activating crRNAsingle-guide RNAStreptococcus pyogenesBacteriaRF02348Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolutionX-ray diffraction3.1722015-07-08
57Z4D|1|ATrans-activating crRNAsgRNAsynthetic constructSyntheticRF02348Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrateX-ray diffraction3.1752022-08-31
67Z4D|1|FTrans-activating crRNAsgRNAsynthetic constructSyntheticRF02348Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrateX-ray diffraction3.1772022-08-31
77Z4L|1|ATrans-activating crRNAsgRNAsynthetic constructSyntheticRF02348SpCas9 bound to 18-nucleotide complementary DNA substrate in the checkpoint stateElectron microscopy2.54962022-08-31
87S4X|1|BTrans-activating crRNAgRNAsynthetic constructSyntheticRF02348Cas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformationElectron microscopy2.76982022-03-02
97Z4J|1|ATrans-activating crRNAsgRNAsynthetic constructSyntheticRF02348SpCas9 bound to 18-nucleotide complementary DNA substrate in the catalytic stateElectron microscopy2.99982022-08-31
106O0X|1|BTrans-activating crRNAsingle guide RNAsynthetic constructSyntheticRF02348Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesiumElectron microscopy3.28982019-07-10
117Z4I|1|ATrans-activating crRNAsgRNAsynthetic constructSyntheticRF02348SpCas9 bound to 16-nucleotide complementary DNA substrateElectron microscopy3.12962022-08-31
127S4V|1|BTrans-activating crRNAgRNAsynthetic constructSyntheticRF02348Cas9 bound to 12-14MM DNA, 60 min time-point, kinked conformationElectron microscopy3.28982022-03-02
136O0Y|1|BTrans-activating crRNAsingle guide RNAsynthetic constructSyntheticRF02348Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesiumElectron microscopy3.37982019-07-10
146O0Z|1|BTrans-activating crRNAsingle guide RNAsynthetic constructSyntheticRF02348Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesiumElectron microscopy3.3962019-07-10
157Z4H|1|ATrans-activating crRNAsgRNAsynthetic constructSyntheticRF02348SpCas9 bound to 14-nucleotide complementary DNA substrateElectron microscopy3.49922022-08-31

Release history

Release3.2463.2473.2483.2493.2503.2513.2523.2533.2543.2553.2563.2573.2583.2593.2603.2613.2623.2633.2643.2653.2663.2673.2683.2693.2703.2713.2723.2733.2743.2753.2763.2773.2783.2793.2803.2813.2823.2833.2843.2853.2863.2873.2883.2893.2903.2913.2923.2933.2943.2953.2963.2973.2983.2993.3003.3013.3023.3033.3043.3053.3063.3073.3083.3093.3103.3113.3123.3133.3143.3153.3163.3173.3183.3193.3203.3213.3223.3233.3243.3253.3263.3273.3283.3293.3303.3313.332
Date2022-08-312022-09-072022-09-142022-09-212022-09-282022-10-052022-10-122022-10-192022-10-262022-11-022022-11-092022-11-162022-11-232022-11-302022-12-072022-12-142022-12-212022-12-282023-01-042023-01-112023-01-182023-01-252023-02-012023-02-082023-02-152023-02-222023-03-012023-03-082023-03-152023-03-222023-03-292023-04-052023-04-122023-04-192023-04-262023-05-032023-05-102023-05-172023-05-242023-05-312023-06-072023-06-142023-06-212023-06-282023-07-052023-07-122023-07-192023-07-262023-08-022023-08-092023-08-162023-08-232023-08-302023-09-062023-09-132023-09-202023-09-272023-10-042023-10-112023-10-182023-10-252023-11-012023-11-082023-11-152023-11-242023-11-292023-12-062023-12-132023-12-202023-12-272024-01-032024-01-102024-01-172024-01-242024-01-312024-02-072024-02-142024-02-212024-02-282024-03-062024-03-132024-03-202024-03-272024-04-032024-04-102024-04-172024-04-24

Parents

This classParent classesRelease idIntersectionAdded to this classOnly in parent
NR_3.5_20965.1NR_3.5_30925.23.246(9) 4ZT0|1|B, 4ZT0|1|D, 4ZT9|1|B, 4ZT9|1|D, 6O0X|1|B, 6O0Y|1|B, 6O0Z|1|B, 7S4V|1|B, 7S4X|1|B(6) 7Z4D|1|A, 7Z4D|1|F, 7Z4H|1|A, 7Z4I|1|A, 7Z4J|1|A, 7Z4L|1|A(0)

Children

This class Descendant classesRelease idIntersectionOnly in this classAdded to child

Instances are ordered to put similar structures near each other. Select one instance to see its 3D structure. Selecting two or more instances will show their superposition, but only chains with identical numbers of observed nucleotides will superpose well. Large structures are slow to display; this tool is not designed for that.

#SViewPDBTitleMethodResolution#NTs
17S4V|1|BCas9 bound to 12-14MM DNA, 60 min time-point, kinked conformationELECTRON MICROSCOPY3.2898
26O0Y|1|BConformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesiumELECTRON MICROSCOPY3.3798
36O0X|1|BConformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesiumELECTRON MICROSCOPY3.2898
46O0Z|1|BConformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesiumELECTRON MICROSCOPY3.396
57Z4H|1|ASpCas9 bound to 14-nucleotide complementary DNA substrateELECTRON MICROSCOPY3.4992
67Z4I|1|ASpCas9 bound to 16-nucleotide complementary DNA substrateELECTRON MICROSCOPY3.1296
77Z4L|1|ASpCas9 bound to 18-nucleotide complementary DNA substrate in the checkpoint stateELECTRON MICROSCOPY2.5496
87Z4J|1|ASpCas9 bound to 18-nucleotide complementary DNA substrate in the catalytic stateELECTRON MICROSCOPY2.9998
97S4X|1|BCas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformationELECTRON MICROSCOPY2.7698
107Z4D|1|ACrystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrateX-RAY DIFFRACTION3.175
117Z4D|1|FCrystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrateX-RAY DIFFRACTION3.177
124ZT9|1|BNuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolutionX-RAY DIFFRACTION3.172
134ZT0|1|BCrystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolutionX-RAY DIFFRACTION2.972
144ZT0|1|DCrystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolutionX-RAY DIFFRACTION2.972
154ZT9|1|DNuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolutionX-RAY DIFFRACTION3.172

Heat map of mutual geometric discrepancy, in Angstroms per nucleotide. The ordering in the heat map is the same as in the table. The colorbar ranges from 0 to the maximum observed discrepancy. Click above the diagonal to select a range of structures, below the diagonal to select two structures.


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