| 1 | 7SOS|1|B (rep) | | RNA (5'-R(*AP*AP*AP*A)-3') | synthetic construct | | | LaM domain of human LARP1 in complex with AAAA RNA | X-ray diffraction | 1.25 | 4 | 2022-08-03 |
| 2 | 6SCE|1|B | | cyclic oligoadenylate | synthetic construct | | | Structure of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate | X-ray diffraction | 1.83 | 4 | 2020-02-19 |
| 3 | 6XL1|1|C | | cA4 | synthetic construct | | | crystal structure of cA4-activated Cad1(D294N) | X-ray diffraction | 1.95 | 4 | 2020-12-30 |
| 4 | 8Q42|1|X | | Cyclic tetraadenosine monophosphate (cA4) | synthetic construct | | | Crystal structure of cA4-bound Can2 (E341A) in complex with oligo-A DNA | X-ray diffraction | 1.97 | 4 | 2023-11-22 |
| 5 | 6SCF|1|I | | cyclic oligoadenylate | synthetic construct | | | A viral anti-CRISPR subverts type III CRISPR immunity by rapid degradation of cyclic oligoadenylate | X-ray diffraction | 1.55 | 4 | 2019-10-30 |
| 6 | 6SCF|1|K | | cyclic oligoadenylate | synthetic construct | | | A viral anti-CRISPR subverts type III CRISPR immunity by rapid degradation of cyclic oligoadenylate | X-ray diffraction | 1.55 | 4 | 2019-10-30 |
| 7 | 6YUD|1|K | | cyclic tetra-adenylate (cA4) | synthetic construct | | | Structure of Csx3/Crn3 from Archaeoglobus fulgidus in complex with cyclic tetra-adenylate (cA4) | X-ray diffraction | 1.84 | 4 | 2020-08-19 |
| 8 | 6YUD|1|O | | cyclic tetra-adenylate (cA4) | synthetic construct | | | Structure of Csx3/Crn3 from Archaeoglobus fulgidus in complex with cyclic tetra-adenylate (cA4) | X-ray diffraction | 1.84 | 4 | 2020-08-19 |
| 9 | 6SCF|1|M | | cyclic oligoadenylate | synthetic construct | | | A viral anti-CRISPR subverts type III CRISPR immunity by rapid degradation of cyclic oligoadenylate | X-ray diffraction | 1.55 | 4 | 2019-10-30 |
| 10 | 6YUD|1|P | | cyclic tetra-adenylate (cA4) | synthetic construct | | | Structure of Csx3/Crn3 from Archaeoglobus fulgidus in complex with cyclic tetra-adenylate (cA4) | X-ray diffraction | 1.84 | 4 | 2020-08-19 |
| 11 | 6SCF|1|L | | cyclic oligoadenylate | synthetic construct | | | A viral anti-CRISPR subverts type III CRISPR immunity by rapid degradation of cyclic oligoadenylate | X-ray diffraction | 1.55 | 4 | 2019-10-30 |
| 12 | 6YUD|1|M | | cyclic tetra-adenylate (cA4) | synthetic construct | | | Structure of Csx3/Crn3 from Archaeoglobus fulgidus in complex with cyclic tetra-adenylate (cA4) | X-ray diffraction | 1.84 | 4 | 2020-08-19 |
| 13 | 6YUD|1|Q | | cyclic tetra-adenylate (cA4) | synthetic construct | | | Structure of Csx3/Crn3 from Archaeoglobus fulgidus in complex with cyclic tetra-adenylate (cA4) | X-ray diffraction | 1.84 | 4 | 2020-08-19 |
| 14 | 8T65|1|C | | RNA (5'-R(P*AP*AP*AP*A)-3') | Nitrosococcus halophilus Nc 4 | | | cA4 bound Cam1 | X-ray diffraction | 2.09 | 4 | 2024-01-10 |
| 15 | 8Q44|1|X | | Cyclic tetraadenosine monophosphate (cA4) | synthetic construct | | | Crystal structure of cA4-bound Can2 (E364R) in complex with oligo-T DNA | X-ray diffraction | 2.3 | 4 | 2023-11-22 |
| 16 | 8Q40|1|X | | Cyclic tetraadenosine monophosphate (cA4) | synthetic construct | | | Crystal structure of cA4 activated Can2 in complex with a cleaved DNA substrate | X-ray diffraction | 2.21 | 4 | 2023-11-22 |
| 17 | 8Q41|1|X | | Cyclic tetraadenosine monophosphate (cA4) | synthetic construct | | | Crystal structure of Can2 (E341A) bound to cA4 and TTTAAA ssDNA | X-ray diffraction | 2.38 | 4 | 2023-11-22 |
| 18 | 6WXQ|1|E | | cyclic tetraadenylate | synthetic construct | | | Crystal structure of CRISPR-associated transcription factor Csa3 complexed with cA4 | X-ray diffraction | 2.05 | 4 | 2021-11-17 |
| 19 | 8Q43|1|X | | Cyclic tetraadenosine monophosphate (cA4) | synthetic construct | | | Crystal structure of cA4-bound Can2 (E341A) in complex with oligo-C DNA | X-ray diffraction | 2.28 | 4 | 2023-11-22 |
| 20 | 8QJK|1|C | | Cyclic tetraadenosine monophosphate (cA4) | synthetic construct | | | Structure of the cytoplasmic domain of csx23 from Vibrio cholera in complex with cyclic tetra-adenylate (cA4) | X-ray diffraction | 1.761 | 4 | 2024-08-07 |
| 21 | 8BAO|1|C | | Cyclic tetra-adenylate (cA4) | synthetic construct | | | Dysgonamonadaceae bacterium CRISPR ancillary nuclease 2 | X-ray diffraction | 2.06 | 4 | 2022-11-30 |
| 22 | 6W11|1|C | | cA4 | Saccharolobus solfataricus | | | The structure of Sulfolobus solfataricus Csa3 in complex with cyclic tetraadenylate (cA4) | X-ray diffraction | 2.46 | 4 | 2021-03-10 |
| 23 | 6O6X|1|D | | Cyclic RNA cA4 | synthetic construct | | | Crystal structure of Csm6 W14A/E337A mutant in complex with cA4 by cocrystallization | X-ray diffraction | 2.11 | 4 | 2019-07-31 |
| 24 | 4BA2|1|R | | 5'-R(*AP*AP*AP*AP)-3' | Saccharolobus solfataricus | | | Archaeal exosome (Rrp4-Rrp41(D182A)-Rrp42) bound to inorganic phosphate | X-ray diffraction | 2.5 | 4 | 2012-10-03 |
| 25 | 7BDV|1|F | | cyclic tetra-adenylate | synthetic construct | | | Structure of Can2 from Sulfobacillus thermosulfidooxidans in complex with cyclic tetra-adenylate (cA4) | X-ray diffraction | 2.02 | 4 | 2021-03-03 |
| 26 | 7DID|1|C | | RNA (5'-R(*AP*AP*AP*A)-3') | Mycoplasma genitalium G37 | | | Mycoplasma genitalium RNase R in complex with ribose methylated single-stranded RNA | X-ray diffraction | 1.9 | 4 | 2021-03-17 |
| 27 | 8B0R|1|D | | RNA (5'-R(P*AP*AP*AP*A)-3') | Sulfurihydrogenibium | | | Structure of the CalpL/cA4 complex | X-ray diffraction | 2.2 | 4 | 2022-11-16 |
| 28 | 7BDV|1|H | | cyclic tetra-adenylate | synthetic construct | | | Structure of Can2 from Sulfobacillus thermosulfidooxidans in complex with cyclic tetra-adenylate (cA4) | X-ray diffraction | 2.02 | 4 | 2021-03-03 |
| 29 | 9C69|1|C | | AAAA | Bacteroidales bacterium | | | The CRISPR associated CARF-adenosine deaminase, Cad1-CARF in the cA4 bound form | X-ray diffraction | 2.4 | 4 | 2024-10-30 |
| 30 | 6O6X|1|C | | Cyclic RNA cA4 | synthetic construct | | | Crystal structure of Csm6 W14A/E337A mutant in complex with cA4 by cocrystallization | X-ray diffraction | 2.11 | 4 | 2019-07-31 |
| 31 | 8Q3Z|1|X | | Cyclic tetraadenosine monophosphate (cA4) | synthetic construct | | | Crystal structure of cA4-bound Can2 from Thermoanaerobacter brockii | X-ray diffraction | 3.15 | 4 | 2023-11-22 |
| 32 | 6O7B|1|C | | Cyclic RNA cA4 | synthetic construct | | | Crystal structure of Csm1-Csm4 cassette in complex with cA4 | X-ray diffraction | 2.4 | 4 | 2019-07-31 |
| 33 | 6O6V|1|C | | Cyclic RNA cA4 | synthetic construct | | | Crystal structure of Csm6 in complex with cA4 by soaking cA4 into Csm6 | X-ray diffraction | 2.35 | 4 | 2019-07-31 |
| 34 | 6WXX|1|Y | | cA4 | synthetic construct | | | crystal structure of cA4-activated Cad1 | X-ray diffraction | 3 | 4 | 2020-12-30 |
| 35 | 6WXX|1|X | | cA4 | synthetic construct | | | crystal structure of cA4-activated Cad1 | X-ray diffraction | 3 | 4 | 2020-12-30 |
| 36 | 6R9R|1|E | | DNA (5'-R(P*AP*AP*AP*A)-3') | synthetic construct | | | Crystal structure of Csx1 in complex with cyclic oligoadenylate cOA4 conformation 2 | X-ray diffraction | 2.7 | 2 | 2019-10-02 |
| 37 | 7YGL|1|C | | RNA (5'-R(*AP*AP*AP*(A23))-3') | synthetic construct | | | Crystal Structure of the ring nuclease Sso2081 from Saccharolobus solfataricus in complex with A4>p cleavage intermediate | X-ray diffraction | 2.5 | 4 | 2023-02-15 |
| 38 | 6R7B|1|D | | RNA (5'-R(P*AP*AP*AP*A)-3') | synthetic construct | | | Crystal structure of Csx1 in complex with cyclic oligoadenylate cOA4 conformation 1 | X-ray diffraction | 3.12 | 4 | 2019-10-02 |
| 39 | 6OV0|1|H | | RNA (5'-R(*AP*AP*AP*(A23))-3') | synthetic construct | | | Crystal structure of Csm6 in complex with A4>p by soaking A4>p into Csm6 | X-ray diffraction | 2.8 | 4 | 2019-07-31 |
| 40 | 6R9R|1|D | | DNA (5'-R(P*AP*AP*AP*A)-3') | synthetic construct | | | Crystal structure of Csx1 in complex with cyclic oligoadenylate cOA4 conformation 2 | X-ray diffraction | 2.7 | 4 | 2019-10-02 |
| 41 | 6OV0|1|E | | RNA (5'-R(*AP*AP*AP*(A23))-3') | synthetic construct | | | Crystal structure of Csm6 in complex with A4>p by soaking A4>p into Csm6 | X-ray diffraction | 2.8 | 4 | 2019-07-31 |
| 42 | 8JH1|1|C | | RNA (5'-R(P*AP*AP*AP*A)-3') | synthetic construct | | | Crystal Structure of the Csm6 Y161A mutant from Thermus thermophilus HB8 in complex with cyclic-tetraadenylate (cA4) | X-ray diffraction | 2.89 | 4 | 2023-12-13 |
| 43 | 7YGH|1|C | | RNA (5'-R(P*AP*AP*AP*A)-3') | synthetic construct | | | Crystal Structure of the ring nuclease Sso2081 from Saccharolobus solfataricus in complex with cyclic-tetraadenylate (cA4) | X-ray diffraction | 3.11 | 4 | 2023-02-15 |
| 44 | 9GU5|1|M | | RNA (5'-R(P*AP*AP*AP*A)-3') | RNA interference vector pBSK-Gus | | | Crystal Structure of Hfq V22A | X-ray diffraction | 2.9 | 4 | 2025-02-05 |
| 45 | 6O6V|1|D | | Cyclic RNA cA4 | synthetic construct | | | Crystal structure of Csm6 in complex with cA4 by soaking cA4 into Csm6 | X-ray diffraction | 2.35 | 4 | 2019-07-31 |
| 46 | 6R7B|1|E | | RNA (5'-R(P*AP*AP*AP*A)-3') | synthetic construct | | | Crystal structure of Csx1 in complex with cyclic oligoadenylate cOA4 conformation 1 | X-ray diffraction | 3.12 | 2 | 2019-10-02 |
| 47 | 8Y7G|1|C | | RNA (5'-R(P*AP*AP*AP*A)-3') | Marinitoga sp. 1155 | | | Crystal structure of the Marinitoga sp. Csx1-Crn2 H495A mutant in complex with cyclic-tetraadenylate (cA4) | X-ray diffraction | 3.15 | 4 | 2024-07-17 |
| 48 | 6O7B|1|D | | Cyclic RNA cA4 | synthetic construct | | | Crystal structure of Csm1-Csm4 cassette in complex with cA4 | X-ray diffraction | 2.4 | 4 | 2019-07-31 |
| 49 | 6OV0|1|G | | RNA (5'-R(*AP*AP*AP*(A23))-3') | synthetic construct | | | Crystal structure of Csm6 in complex with A4>p by soaking A4>p into Csm6 | X-ray diffraction | 2.8 | 3 | 2019-07-31 |
| 50 | 6OV0|1|F | | RNA (5'-R(*AP*AP*AP*(A23))-3') | synthetic construct | | | Crystal structure of Csm6 in complex with A4>p by soaking A4>p into Csm6 | X-ray diffraction | 2.8 | 3 | 2019-07-31 |
| 51 | 5E02|1|C | | RNA (5'-R(*AP*AP*AP*A)-3') | synthetic construct | | | Structure of RNA Helicase FRH a Critical Component of the Neurospora Crassa Circadian Clock | X-ray diffraction | 3.8 | 4 | 2016-07-06 |
| 52 | 7Z55|1|CCC | | Cyclic RNA cA4 | synthetic construct | | | Crystal Structure of the Ring Nuclease 0455 from Sulfolobus islandicus (Sis0455) in complex with its substrate | X-ray diffraction | 1.664 | 4 | 2022-11-23 |
| 53 | 9EYK|1|E | | A4>p (5'-R(*AP*AP*AP*(A23))-3') | synthetic construct | | | Cryo-EM structure of SAVED-Lon protease CCaCalpL filament bound to A4>p | Electron microscopy | 2.84 | 4 | 2024-10-02 |
| 54 | 9EYJ|1|D | | cA4 | synthetic construct | | | Cryo-EM structure of SAVED-Lon protease CCaCalpL filament bound to cA4 | Electron microscopy | 2.97 | 4 | 2024-10-02 |
| 55 | 9C77|1|G | | RNA (5'-R(P*AP*AP*AP*A)-3') | Bacteroidales bacterium | | | cryoEM structure of CRISPR associated effector, CARF-Adenosine deaminase 1, Cad1, in cA4 bound form with ATP. | Electron microscopy | 3.2 | 4 | 2024-10-30 |
| 56 | 9C77|1|H | | RNA (5'-R(P*AP*AP*AP*A)-3') | Bacteroidales bacterium | | | cryoEM structure of CRISPR associated effector, CARF-Adenosine deaminase 1, Cad1, in cA4 bound form with ATP. | Electron microscopy | 3.2 | 4 | 2024-10-30 |
| 57 | 6O7I|1|I | | RNA (5'-R(P*AP*AP*AP*A)-3') | synthetic construct | | | Cryo-EM structure of Csm-crRNA-target RNA ternary bigger complex in complex with cA4 in type III-A CRISPR-Cas system | Electron microscopy | 3.2 | 4 | 2019-07-31 |
| 58 | 9C77|1|I | | RNA (5'-R(P*AP*AP*AP*A)-3') | Bacteroidales bacterium | | | cryoEM structure of CRISPR associated effector, CARF-Adenosine deaminase 1, Cad1, in cA4 bound form with ATP. | Electron microscopy | 3.2 | 4 | 2024-10-30 |
| 59 | 9EYI|1|D | | A4p (5'-R(*AP*AP*AP*AP)-3') | synthetic construct | | | Cryo-EM structure of SAVED-Lon protease CCaCalpL filament bound to A4p | Electron microscopy | 2.75 | 4 | 2024-10-02 |
| 60 | 9EYI|1|E | | A4p (5'-R(*AP*AP*AP*AP)-3') | synthetic construct | | | Cryo-EM structure of SAVED-Lon protease CCaCalpL filament bound to A4p | Electron microscopy | 2.75 | 4 | 2024-10-02 |
| 61 | 9EYK|1|D | | A4>p (5'-R(*AP*AP*AP*(A23))-3') | synthetic construct | | | Cryo-EM structure of SAVED-Lon protease CCaCalpL filament bound to A4>p | Electron microscopy | 2.84 | 4 | 2024-10-02 |
| 62 | 8PHJ|1|Z | | Cyclic tetraadenosine monophosphate (cA4) | Streptococcus thermophilus | | | cA4-bound Cami1 in complex with 70S ribosome | Electron microscopy | 3.67 | 4 | 2023-12-13 |
| 63 | 6O7H|1|K | | Cyclic DNA cA4 | synthetic construct | | | Cryo-EM structure of Csm-crRNA-target RNA ternary complex in complex with cA4 in type III-A CRISPR-Cas system | Electron microscopy | 2.9 | 4 | 2019-07-31 |