#IFEStandardized nameMoleculeOrganismSourceRfamTitleMethodRes. ÅDate
18H6L|1|5A (rep)U5 spliceosomal RNApre-mRNA, U5 snRNA, U6 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of human exon-defined spliceosome in the early B state.Electron microscopy2.62024-05-01
28H6K|1|5AU5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of human exon-defined spliceosome in the mature B state.Electron microscopy2.72024-05-01
38C6J|1|5U5 spliceosomal RNAPM5 5' Exon, U5 snRNAHomo sapiensEukaryaRF00020Human spliceosomal PM5 C* complexElectron microscopy2.82023-07-12
46QW6|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution.Electron microscopy2.922019-04-17
57DVQ|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)Electron microscopy2.892021-03-31
67QTT|1|eU5 spliceosomal RNAMINX, U5 snRNAHomo sapiensEukaryaRF00020Structural organization of a late activated human spliceosome (Baqr, core region)Electron microscopy3.12023-05-10
78Q7N|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)Electron microscopy3.12024-01-24
88H6E|1|5AU5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.Electron microscopy3.22024-05-01
98H6J|1|5AU5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.Electron microscopy3.252024-05-01
108Q7Q|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2)Electron microscopy3.22024-04-17
118Q91|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the human 20S U5 snRNP coreElectron microscopy3.12024-03-27
126QX9|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).Electron microscopy3.282019-04-17
138RC0|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the human 20S U5 snRNPElectron microscopy3.22024-03-27
146QDV|1|5U5 spliceosomal RNALigated exons: MINX mRNA, U5 snRNAHomo sapiensEukaryaRF00020Human post-catalytic P complex spliceosomeElectron microscopy3.32019-02-20
156ZYM|1|5U5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Human C Complex Spliceosome - High-resolution COREElectron microscopy3.42020-10-14
168Y6O|1|BU5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP partElectron microscopy3.382024-03-20
176ICZ|1|BU5 spliceosomal RNApre-mRNA, U5snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstromElectron microscopy32019-03-13
187W59|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020The cryo-EM structure of human pre-C*-I complexElectron microscopy3.62022-06-22
197W5A|1|BU5 spliceosomal RNAPre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020The cryo-EM structure of human pre-C*-II complexElectron microscopy3.62022-06-22
206FF4|1|5U5 spliceosomal RNApre mRNA, U2 snRNA, U5 snRNAHomo sapiensEukaryaRF00020human Bact spliceosome core structureElectron microscopy3.42018-08-29
218Q7V|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1)Electron microscopy3.82024-04-17
226ID0|1|BU5 spliceosomal RNAU5snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolutionElectron microscopy2.92019-03-13
235XJC|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstromElectron microscopy3.62017-07-05
248Q7W|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3)Electron microscopy3.92024-04-17
256ID1|1|BU5 spliceosomal RNAU5snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolutionElectron microscopy2.862019-03-13
267W5B|1|BU5 spliceosomal RNAPre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020The cryo-EM structure of human C* complexElectron microscopy4.32022-06-22
277AAV|1|5U5 spliceosomal RNAMINX M3 pre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Human pre-Bact-2 spliceosome core structureElectron microscopy4.22020-12-09
285YZG|1|BU5 spliceosomal RNAPre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolutionElectron microscopy4.12018-08-08
296AHD|1|BU5 spliceosomal RNApre-mRNA, U5snRNAHomo sapiensEukaryaRF00020The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolutionElectron microscopy3.82018-11-14
305O9Z|1|5U5 spliceosomal RNAHomo sapiens U5 A small nuclear RNA, MINX pre-mRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex)Electron microscopy4.52017-08-16
318Q7X|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4)Electron microscopy4.62024-04-17
326FF7|1|5U5 spliceosomal RNApre-mRNA, U2 snRNA, U5 snRNAHomo sapiensEukaryaRF00020human Bact spliceosome core structureElectron microscopy4.52019-03-13
337ABF|1|5U5 spliceosomal RNAMINX M3 RNA, U5 small nuclear RNAHomo sapiensEukaryaRF00020Human pre-Bact-1 spliceosome core structureElectron microscopy3.92020-12-09
348QO9|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a human spliceosomal B complex protomerElectron microscopy5.292024-01-24
355Z58|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.Electron microscopy4.92018-09-19
367A5P|1|5U5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF00020Human C Complex Spliceosome - Medium-resolution PERIPHERYElectron microscopy52020-10-14
375Z56|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.Electron microscopy5.12018-09-19
388CH6|1|eU5 spliceosomal RNAMINX-M3, RNU5A-1Homo sapiensEukaryaRF00020Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).Electron microscopy5.92023-05-10
396AH0|1|BU5 spliceosomal RNAU5snRNAHomo sapiensEukaryaRF00020The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex)Electron microscopy5.72018-11-14
405MQF|1|5U5 spliceosomal RNAHomo sapiens U5 A small nuclear RNA, MINX pre-mRNA (intron)Homo sapiensEukaryaRF00020Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex)Electron microscopy5.92017-03-22
415Z57|1|BU5 spliceosomal RNApre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstromElectron microscopy6.52018-09-19
423JCR|1|HU5 spliceosomal RNAU5 snRNAHomo sapiensEukaryaRF000203D structure determination of the human*U4/U6.U5* tri-snRNP complexElectron microscopy72016-03-09
437ABG|1|5U5 spliceosomal RNAMINX M3 pre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Human pre-Bact-1 spliceosomeElectron microscopy7.82020-12-23
447ABI|1|5U5 spliceosomal RNAMINX M3 pre-mRNA, U5 snRNAHomo sapiensEukaryaRF00020Human pre-Bact-2 spliceosomeElectron microscopy82021-02-10

Release history

Release3.3333.3343.335
Date2024-05-012024-05-082024-05-15

Parents

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Instances are ordered to put similar structures near each other. Select one instance to see its 3D structure. Selecting two or more instances will show their superposition, but only chains with identical numbers of observed nucleotides will superpose well. Large structures are slow to display; this tool is not designed for that.

#SViewPDBTitleMethodResolutionLength
15Z58|1|BCryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.ELECTRON MICROSCOPY4.984
25Z56|1|Bcryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.ELECTRON MICROSCOPY5.184
35Z57|1|BCryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstromELECTRON MICROSCOPY6.584
45YZG|1|BThe Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolutionELECTRON MICROSCOPY4.184
55XJC|1|BCryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstromELECTRON MICROSCOPY3.684
68CH6|1|eStructure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).ELECTRON MICROSCOPY5.998
77QTT|1|eStructural organization of a late activated human spliceosome (Baqr, core region)ELECTRON MICROSCOPY3.198
87W5B|1|BThe cryo-EM structure of human C* complexELECTRON MICROSCOPY4.384
97W5A|1|BThe cryo-EM structure of human pre-C*-II complexELECTRON MICROSCOPY3.684
107W59|1|BThe cryo-EM structure of human pre-C*-I complexELECTRON MICROSCOPY3.684
116ID1|1|BCryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolutionELECTRON MICROSCOPY2.8698
126ID0|1|BCryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolutionELECTRON MICROSCOPY2.998
136ICZ|1|BCryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstromELECTRON MICROSCOPY397
147DVQ|1|BCryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)ELECTRON MICROSCOPY2.8990
156QDV|1|5Human post-catalytic P complex spliceosomeELECTRON MICROSCOPY3.375
168C6J|1|5Human spliceosomal PM5 C* complexELECTRON MICROSCOPY2.8113
176QX9|1|5Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).ELECTRON MICROSCOPY3.28104
186QW6|1|5Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution.ELECTRON MICROSCOPY2.92104
198Q91|1|5Structure of the human 20S U5 snRNP coreELECTRON MICROSCOPY3.1104
208RC0|1|5Structure of the human 20S U5 snRNPELECTRON MICROSCOPY3.2104
218Q7X|1|5Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4)ELECTRON MICROSCOPY4.6104
228Q7W|1|5Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3)ELECTRON MICROSCOPY3.9104
238Q7Q|1|5Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2)ELECTRON MICROSCOPY3.2104
248Q7V|1|5Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1)ELECTRON MICROSCOPY3.8104
258Y6O|1|BCryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP partELECTRON MICROSCOPY3.38109
268H6J|1|5ACryo-EM structure of human exon-defined spliceosome in the mature pre-B state.ELECTRON MICROSCOPY3.25114
278H6E|1|5ACryo-EM structure of human exon-defined spliceosome in the late pre-B state.ELECTRON MICROSCOPY3.2114
287ABF|1|5Human pre-Bact-1 spliceosome core structureELECTRON MICROSCOPY3.958
297ABG|1|5Human pre-Bact-1 spliceosomeELECTRON MICROSCOPY7.8114
307AAV|1|5Human pre-Bact-2 spliceosome core structureELECTRON MICROSCOPY4.269
317ABI|1|5Human pre-Bact-2 spliceosomeELECTRON MICROSCOPY8114
326FF7|1|5human Bact spliceosome core structureELECTRON MICROSCOPY4.570
336FF4|1|5human Bact spliceosome core structureELECTRON MICROSCOPY3.470
346ZYM|1|5Human C Complex Spliceosome - High-resolution COREELECTRON MICROSCOPY3.474
358QO9|1|5Cryo-EM structure of a human spliceosomal B complex protomerELECTRON MICROSCOPY5.29115
368Q7N|1|5cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)ELECTRON MICROSCOPY3.1115
378H6K|1|5ACryo-EM structure of human exon-defined spliceosome in the mature B state.ELECTRON MICROSCOPY2.7115
388H6L|1|5ACryo-EM structure of human exon-defined spliceosome in the early B state.ELECTRON MICROSCOPY2.6115
396AHD|1|BThe Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolutionELECTRON MICROSCOPY3.8115
406AH0|1|BThe Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex)ELECTRON MICROSCOPY5.7115
415O9Z|1|5Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex)ELECTRON MICROSCOPY4.5114
425MQF|1|5Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex)ELECTRON MICROSCOPY5.9114
437A5P|1|5Human C Complex Spliceosome - Medium-resolution PERIPHERYELECTRON MICROSCOPY540
443JCR|1|H3D structure determination of the human*U4/U6.U5* tri-snRNP complexELECTRON MICROSCOPY763

Heat map of mutual geometric discrepancy, in Angstroms per nucleotide. The ordering in the heat map is the same as in the table. The colorbar ranges from 0 to the maximum observed discrepancy. Click above the diagonal to select a range of structures, below the diagonal to select two structures.


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