1 | 2P7E|1|D+ 2P7E|1|C+ 2P7E|1|P (rep) | | 3' substrate strand, octameric fragment, Ribozyme strand II, Ribozyme strand III | | | | Vanadate at the Active Site of a Small Ribozyme Suggests a Role for Water in Transition-State Stabilization | X-ray diffraction | 2.05 | 2007-05-22 |
2 | 2D2K|1|D+ 2D2K|1|C+ 2D2K|1|A+ 2D2K|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*UP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | Crystal Structure of a minimal, native (U39) all-RNA hairpin ribozyme | X-ray diffraction | 2.65 | 2005-11-01 |
3 | 3I2R|1|C | | 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | Crystal structure of the hairpin ribozyme with a 2',5'-linked substrate with N1-deazaadenosine at position A9 | X-ray diffraction | 2.8 | 2009-11-03 |
4 | 3I2U|1|C | | 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | Crystal structure of the haiprin ribozyme with a 2',5'-linked substrate and N1-deazaadenosine at position A10 | X-ray diffraction | 2.8 | 2009-11-03 |
5 | 3I2Q|1|C | | 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | Crystal structure of the hairpin ribozyme with 2'OMe substrate strand and N1-deazaadenosine at position A9 | X-ray diffraction | 2.9 | 2009-11-03 |
6 | 3CQS|1|C | | 19-mer ribozyme strand | | | | A 3'-OH, 2',5'-phosphodiester substitution in the hairpin ribozyme active site reveals similarities with protein ribonucleases | X-ray diffraction | 2.8 | 2008-05-20 |
7 | 3CR1|1|C | | RNA (5'-R(*UP*CP*GP*UP*GP*GP*UP*CP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3') | | | | crystal structure of a minimal, mutant, all-RNA hairpin ribozyme (A38C, A-1OMA) grown from MgCl2 | X-ray diffraction | 2.25 | 2008-08-26 |
8 | 3I2S|1|C | | 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | Crystal structure of the hairpin ribozyme with a 2'OMe substrate and N1-deazaadenosine at position A10 | X-ray diffraction | 2.75 | 2009-11-03 |
9 | 3GS8|1|D+ 3GS8|1|C+ 3GS8|1|A+ 3GS8|1|B | | RNA (5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3'), RNA (5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*GP*U)-3'), RNA (5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3'), RNA (5'-R(P*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3') | | | | An all-RNA hairpin ribozyme A38N1dA38 variant with a transition-state mimic substrate strand | X-ray diffraction | 2.85 | 2009-04-21 |
10 | 1ZFV|1|D+ 1ZFV|1|C+ 1ZFV|1|A+ 1ZFV|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*AP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | The structure of an all-RNA minimal Hairpin Ribozyme with Mutation G8A at the cleavage site | X-ray diffraction | 2.4 | 2006-02-14 |
11 | 4G6R|1|D+ 4G6R|1|C+ 4G6R|1|A+ 4G6R|1|B | | Loop A Ribozyme strand, Loop A Substrate strand, Loop B Ribozyme Strand, Loop B S-turn strand | | | | Minimal Hairpin Ribozyme in the Transition State with G8I Variation | X-ray diffraction | 2.83 | 2012-08-15 |
12 | 2P7D|1|D+ 2P7D|1|C+ 2P7D|1|P | | 3' substrate strand, octameric fragment, Ribozyme strand II, Ribozyme strand III | | | | A Minimal, 'Hinged' Hairpin Ribozyme Construct Solved with Mimics of the Product Strands at 2.25 Angstroms Resolution | X-ray diffraction | 2.25 | 2007-05-22 |
13 | 1X9K|1|D+ 1X9K|1|C+ 1X9K|1|A+ 1X9K|1|B | | 5'-R(*AP*AP*UP*AP*GP*AP*GP*AP*AP*GP*CP*GP*A)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*GP*CP*AP*GP*UP*CP*CP*UP*AP*UP*U)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | An all-RNA Hairpin Ribozyme with mutation U39C | X-ray diffraction | 3.17 | 2005-11-22 |
14 | 2NPZ|1|D+ 2NPZ|1|C+ 2NPZ|1|A+ 2NPZ|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | Crystal structure of junctioned hairpin ribozyme incorporating synthetic propyl linker | X-ray diffraction | 3.35 | 2007-08-14 |
15 | 1X9C|1|D+ 1X9C|1|C+ 1X9C|1|A+ 1X9C|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | An all-RNA Hairpin Ribozyme with mutation U39C | X-ray diffraction | 2.19 | 2005-11-22 |
16 | 3GS1|1|D+ 3GS1|1|C+ 3GS1|1|A+ 3GS1|1|B | | RNA (5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3'), RNA (5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*GP*U)-3'), RNA (5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3'), RNA (5'-R(P*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3') | | | | An all-RNA Hairpin Ribozyme with mutation A38N1dA | X-ray diffraction | 2.85 | 2009-05-12 |
17 | 2BCZ|1|D+ 2BCZ|1|C+ 2BCZ|1|A+ 2BCZ|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*IP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*(DA)P*GP*UP*CP*CP*AP*CP*CP*G)-3'), 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8I, 2'deoxy A-1) | X-ray diffraction | 2.4 | 2006-02-14 |
18 | 2NPY|1|D+ 2NPY|1|C+ 2NPY|1|A+ 2NPY|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*(U2N)P*GP*UP*CP*CP*AP*CP*CP*G)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1 | X-ray diffraction | 2.65 | 2007-08-14 |
19 | 2OUE|1|D+ 2OUE|1|C+ 2OUE|1|A+ 2OUE|1|B | | Loop A ribozyme strand, Loop B ribozyme strand, Loop B S-turn strand, Substrate strand - Minimal Junctionless Hairpin Ribozyme | | | | Crystal structure of a junctionless all-RNA hairpin ribozyme at 2.05 angstroms resolution | X-ray diffraction | 2.05 | 2007-03-06 |
20 | 2BCY|1|D+ 2BCY|1|C+ 2BCY|1|A+ 2BCY|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*(MTU)P*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8MTU) | X-ray diffraction | 2.7 | 2006-02-14 |
21 | 1ZFT|1|D+ 1ZFT|1|C+ 1ZFT|1|A+ 1ZFT|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*IP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | The crystal structure of an all-RNA minimal Hairpin Ribozyme with mutant G8I at the cleavage site | X-ray diffraction | 2.33 | 2006-02-14 |
22 | 2FGP|1|D+ 2FGP|1|C+ 2FGP|1|A+ 2FGP|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*(N6G)P*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C) -3' | | | | Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6 | X-ray diffraction | 2.4 | 2006-02-14 |
23 | 1ZFX|1|D+ 1ZFX|1|C+ 1ZFX|1|A+ 1ZFX|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*UP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | The Structure of a minimal all-RNA Hairpin Ribozyme with the mutant G8U at the cleavage site | X-ray diffraction | 2.38 | 2006-02-14 |
24 | 2P7F|1|D+ 2P7F|1|C+ 2P7F|1|A+ 2P7F|1|B | | Loop A ribozyme strand, Loop B ribozyme strand, Loop B S-turn strand, substrate strand | | | | The Novel Use of a 2',5'-Phosphodiester Linkage as a Reaction Intermediate at the Active Site of a Small Ribozyme | X-ray diffraction | 2.35 | 2007-05-22 |
25 | 2D2L|1|D+ 2D2L|1|C+ 2D2L|1|A+ 2D2L|1|B | | 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3', 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*(P1P)P*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' | | | | Crystal Structure of a minimal, all-RNA hairpin ribozyme with a propyl linker (C3) at position U39 | X-ray diffraction | 2.5 | 2005-11-01 |