Equivalence class NR_4.0_20965.1 Current
| # | IFE | Compound(s) | RNA source organism | Title | Method | Resolution | Date |
|---|---|---|---|---|---|---|---|
| 1 | 4ZT0|1|D (rep) | single-guide RNA | Streptococcus pyogenes | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-RAY DIFFRACTION | 2.9 | 2015-07-08 |
| 2 | 4ZT0|1|B | single-guide RNA | Streptococcus pyogenes | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-RAY DIFFRACTION | 2.9 | 2015-07-08 |
| 3 | 4ZT9|1|D | single-guide RNA | Streptococcus pyogenes | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-RAY DIFFRACTION | 3.1 | 2015-07-08 |
| 4 | 4ZT9|1|B | single-guide RNA | Streptococcus pyogenes | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-RAY DIFFRACTION | 3.1 | 2015-07-08 |
| 5 | 7Z4D|1|A | sgRNA | synthetic construct | Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrate | X-RAY DIFFRACTION | 3.1 | 2022-08-31 |
| 6 | 7Z4D|1|F | sgRNA | synthetic construct | Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrate | X-RAY DIFFRACTION | 3.1 | 2022-08-31 |
| 7 | 7Z4L|1|A | sgRNA | synthetic construct | SpCas9 bound to 18-nucleotide complementary DNA substrate in the checkpoint state | ELECTRON MICROSCOPY | 2.54 | 2022-08-31 |
| 8 | 7S4X|1|B | gRNA | synthetic construct | Cas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformation | ELECTRON MICROSCOPY | 2.76 | 2022-03-02 |
| 9 | 7Z4J|1|A | sgRNA | synthetic construct | SpCas9 bound to 18-nucleotide complementary DNA substrate in the catalytic state | ELECTRON MICROSCOPY | 2.99 | 2022-08-31 |
| 10 | 6O0X|1|B | single guide RNA | synthetic construct | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.28 | 2019-07-10 |
| 11 | 7Z4I|1|A | sgRNA | synthetic construct | SpCas9 bound to 16-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.12 | 2022-08-31 |
| 12 | 7S4V|1|B | gRNA | synthetic construct | Cas9 bound to 12-14MM DNA, 60 min time-point, kinked conformation | ELECTRON MICROSCOPY | 3.28 | 2022-03-02 |
| 13 | 6O0Y|1|B | single guide RNA | synthetic construct | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.37 | 2019-07-10 |
| 14 | 6O0Z|1|B | single guide RNA | synthetic construct | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.3 | 2019-07-10 |
| 15 | 7S4U|1|B | gRNA | synthetic construct | Cryo-EM structure of Cas9 in complex with 12-14MM DNA substrate, 5 minute time-point | ELECTRON MICROSCOPY | 3.56 | 2022-03-02 |
| 16 | 7Z4H|1|A | sgRNA | synthetic construct | SpCas9 bound to 14-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.49 | 2022-08-31 |
| 17 | 7Z4G|1|A | sgRNA | synthetic construct | SpCas9 bound to 12-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.64 | 2022-08-31 |
| 18 | 7Z4C|1|A | sgRNA | synthetic construct | SpCas9 bound to 6 nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.87 | 2022-08-31 |
| 19 | 7Z4K|1|A | sgRNA | synthetic construct | SpCas9 bound to 10-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.81 | 2022-08-31 |
Parents
| This class | Parent classes | Release id | Intersection | Added to this class | Only in parent |
|---|---|---|---|---|---|
| NR_4.0_20965.1 | NR_4.0_30925.2 | 3.246 | (10) 4ZT9|1|B, 6O0Z|1|B, 7S4X|1|B, 6O0Y|1|B, 4ZT0|1|D, 7S4V|1|B, 6O0X|1|B, 4ZT0|1|B, 7S4U|1|B, 4ZT9|1|D | (9) 7Z4H|1|A, 7Z4C|1|A, 7Z4I|1|A, 7Z4G|1|A, 7Z4L|1|A, 7Z4D|1|F, 7Z4K|1|A, 7Z4D|1|A, 7Z4J|1|A | (0) |
Children
| This class | Descendant classes | Release id | Intersection | Only in this class | Added to child |
|---|
Heat map of mutual geometric discrepancy, in Angstroms per nucleotide. Instances are ordered to put similar structures near each other. The colorbar ranges from 0 to the maximum observed discrepancy, up to 0.5
#S - ordering by similarity (same as in the heat map).| #S | PDB | Title | Method | Resolution | Length |
|---|---|---|---|---|---|
| 1 | 7S4U|1|B | Cryo-EM structure of Cas9 in complex with 12-14MM DNA substrate, 5 minute time-point | ELECTRON MICROSCOPY | 3.56 | 97 |
| 2 | 7Z4C|1|A | SpCas9 bound to 6 nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.87 | 90 |
| 3 | 7Z4L|1|A | SpCas9 bound to 18-nucleotide complementary DNA substrate in the checkpoint state | ELECTRON MICROSCOPY | 2.54 | 96 |
| 4 | 7Z4I|1|A | SpCas9 bound to 16-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.12 | 96 |
| 5 | 7Z4G|1|A | SpCas9 bound to 12-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.64 | 91 |
| 6 | 7Z4H|1|A | SpCas9 bound to 14-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.49 | 92 |
| 7 | 7Z4K|1|A | SpCas9 bound to 10-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.81 | 88 |
| 8 | 7Z4J|1|A | SpCas9 bound to 18-nucleotide complementary DNA substrate in the catalytic state | ELECTRON MICROSCOPY | 2.99 | 98 |
| 9 | 7S4X|1|B | Cas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformation | ELECTRON MICROSCOPY | 2.76 | 98 |
| 10 | 7Z4D|1|F | Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrate | X-RAY DIFFRACTION | 3.1 | 77 |
| 11 | 7Z4D|1|A | Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrate | X-RAY DIFFRACTION | 3.1 | 75 |
| 12 | 7S4V|1|B | Cas9 bound to 12-14MM DNA, 60 min time-point, kinked conformation | ELECTRON MICROSCOPY | 3.28 | 98 |
| 13 | 6O0Y|1|B | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.37 | 98 |
| 14 | 6O0X|1|B | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.28 | 98 |
| 15 | 6O0Z|1|B | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.3 | 96 |
| 16 | 4ZT9|1|B | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-RAY DIFFRACTION | 3.1 | 72 |
| 17 | 4ZT0|1|B | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-RAY DIFFRACTION | 2.9 | 72 |
| 18 | 4ZT0|1|D | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-RAY DIFFRACTION | 2.9 | 72 |
| 19 | 4ZT9|1|D | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-RAY DIFFRACTION | 3.1 | 72 |