Equivalence class NR_4.0_20965.1 Current
| # | IFE | Standardized name | Molecule | Organism | Source | Rfam | Title | Method | Res. Å | Date |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4ZT0|1|D (rep) | single-guide RNA | Streptococcus pyogenes | Bacteria | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-ray diffraction | 2.9 | 2015-07-08 | ||
| 2 | 4ZT0|1|B | single-guide RNA | Streptococcus pyogenes | Bacteria | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-ray diffraction | 2.9 | 2015-07-08 | ||
| 3 | 4ZT9|1|D | single-guide RNA | Streptococcus pyogenes | Bacteria | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-ray diffraction | 3.1 | 2015-07-08 | ||
| 4 | 4ZT9|1|B | single-guide RNA | Streptococcus pyogenes | Bacteria | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-ray diffraction | 3.1 | 2015-07-08 | ||
| 5 | 7Z4D|1|A | sgRNA | synthetic construct | Synthetic | Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrate | X-ray diffraction | 3.1 | 2022-08-31 | ||
| 6 | 7Z4D|1|F | sgRNA | synthetic construct | Synthetic | Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrate | X-ray diffraction | 3.1 | 2022-08-31 | ||
| 7 | 7Z4L|1|A | sgRNA | synthetic construct | Synthetic | SpCas9 bound to 18-nucleotide complementary DNA substrate in the checkpoint state | Electron microscopy | 2.54 | 2022-08-31 | ||
| 8 | 7S4X|1|B | gRNA | synthetic construct | Synthetic | Cas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformation | Electron microscopy | 2.76 | 2022-03-02 | ||
| 9 | 7Z4J|1|A | sgRNA | synthetic construct | Synthetic | SpCas9 bound to 18-nucleotide complementary DNA substrate in the catalytic state | Electron microscopy | 2.99 | 2022-08-31 | ||
| 10 | 6O0X|1|B | single guide RNA | synthetic construct | Synthetic | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | Electron microscopy | 3.28 | 2019-07-10 | ||
| 11 | 7Z4I|1|A | sgRNA | synthetic construct | Synthetic | SpCas9 bound to 16-nucleotide complementary DNA substrate | Electron microscopy | 3.12 | 2022-08-31 | ||
| 12 | 7S4V|1|B | gRNA | synthetic construct | Synthetic | Cas9 bound to 12-14MM DNA, 60 min time-point, kinked conformation | Electron microscopy | 3.28 | 2022-03-02 | ||
| 13 | 6O0Y|1|B | single guide RNA | synthetic construct | Synthetic | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | Electron microscopy | 3.37 | 2019-07-10 | ||
| 14 | 6O0Z|1|B | single guide RNA | synthetic construct | Synthetic | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | Electron microscopy | 3.3 | 2019-07-10 | ||
| 15 | 7S4U|1|B | gRNA | synthetic construct | Synthetic | Cryo-EM structure of Cas9 in complex with 12-14MM DNA substrate, 5 minute time-point | Electron microscopy | 3.56 | 2022-03-02 | ||
| 16 | 7Z4H|1|A | sgRNA | synthetic construct | Synthetic | SpCas9 bound to 14-nucleotide complementary DNA substrate | Electron microscopy | 3.49 | 2022-08-31 | ||
| 17 | 7Z4G|1|A | sgRNA | synthetic construct | Synthetic | SpCas9 bound to 12-nucleotide complementary DNA substrate | Electron microscopy | 3.64 | 2022-08-31 | ||
| 18 | 7Z4C|1|A | sgRNA | synthetic construct | Synthetic | SpCas9 bound to 6 nucleotide complementary DNA substrate | Electron microscopy | 3.87 | 2022-08-31 | ||
| 19 | 7Z4K|1|A | sgRNA | synthetic construct | Synthetic | SpCas9 bound to 10-nucleotide complementary DNA substrate | Electron microscopy | 3.81 | 2022-08-31 |
Release history
| Release | 3.246 | 3.247 | 3.248 | 3.249 | 3.250 | 3.251 | 3.252 | 3.253 | 3.254 | 3.255 | 3.256 | 3.257 | 3.258 | 3.259 | 3.260 | 3.261 | 3.262 | 3.263 | 3.264 | 3.265 | 3.266 | 3.267 | 3.268 | 3.269 | 3.270 | 3.271 | 3.272 | 3.273 | 3.274 | 3.275 | 3.276 | 3.277 | 3.278 | 3.279 | 3.280 | 3.281 | 3.282 | 3.283 | 3.284 | 3.285 | 3.286 | 3.287 | 3.288 | 3.289 | 3.290 | 3.291 | 3.292 | 3.293 | 3.294 | 3.295 | 3.296 | 3.297 | 3.298 | 3.299 | 3.300 | 3.301 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Date | 2022-08-31 | 2022-09-07 | 2022-09-14 | 2022-09-21 | 2022-09-28 | 2022-10-05 | 2022-10-12 | 2022-10-19 | 2022-10-26 | 2022-11-02 | 2022-11-09 | 2022-11-16 | 2022-11-23 | 2022-11-30 | 2022-12-07 | 2022-12-14 | 2022-12-21 | 2022-12-28 | 2023-01-04 | 2023-01-11 | 2023-01-18 | 2023-01-25 | 2023-02-01 | 2023-02-08 | 2023-02-15 | 2023-02-22 | 2023-03-01 | 2023-03-08 | 2023-03-15 | 2023-03-22 | 2023-03-29 | 2023-04-05 | 2023-04-12 | 2023-04-19 | 2023-04-26 | 2023-05-03 | 2023-05-10 | 2023-05-17 | 2023-05-24 | 2023-05-31 | 2023-06-07 | 2023-06-14 | 2023-06-21 | 2023-06-28 | 2023-07-05 | 2023-07-12 | 2023-07-19 | 2023-07-26 | 2023-08-02 | 2023-08-09 | 2023-08-16 | 2023-08-23 | 2023-08-30 | 2023-09-06 | 2023-09-13 | 2023-09-20 |
Parents
| This class | Parent classes | Release id | Intersection | Added to this class | Only in parent |
|---|---|---|---|---|---|
| NR_4.0_20965.1 | NR_4.0_30925.2 | 3.246 | (10) 6O0Z|1|B, 4ZT9|1|D, 4ZT9|1|B, 7S4X|1|B, 6O0Y|1|B, 4ZT0|1|D, 7S4V|1|B, 6O0X|1|B, 4ZT0|1|B, 7S4U|1|B | (9) 7Z4J|1|A, 7Z4D|1|A, 7Z4I|1|A, 7Z4C|1|A, 7Z4H|1|A, 7Z4L|1|A, 7Z4G|1|A, 7Z4K|1|A, 7Z4D|1|F | (0) |
Children
| This class | Descendant classes | Release id | Intersection | Only in this class | Added to child |
|---|
Heat map of mutual geometric discrepancy, in Angstroms per nucleotide. Instances are ordered to put similar structures near each other. The colorbar ranges from 0 to the maximum observed discrepancy, up to 0.5
#S - ordering by similarity (same as in the heat map).| #S | PDB | Title | Method | Resolution | Length |
|---|---|---|---|---|---|
| 1 | 7S4U|1|B | Cryo-EM structure of Cas9 in complex with 12-14MM DNA substrate, 5 minute time-point | ELECTRON MICROSCOPY | 3.56 | 97 |
| 2 | 7Z4C|1|A | SpCas9 bound to 6 nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.87 | 90 |
| 3 | 7Z4I|1|A | SpCas9 bound to 16-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.12 | 96 |
| 4 | 7Z4L|1|A | SpCas9 bound to 18-nucleotide complementary DNA substrate in the checkpoint state | ELECTRON MICROSCOPY | 2.54 | 96 |
| 5 | 7Z4G|1|A | SpCas9 bound to 12-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.64 | 91 |
| 6 | 7Z4H|1|A | SpCas9 bound to 14-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.49 | 92 |
| 7 | 7Z4K|1|A | SpCas9 bound to 10-nucleotide complementary DNA substrate | ELECTRON MICROSCOPY | 3.81 | 88 |
| 8 | 7Z4J|1|A | SpCas9 bound to 18-nucleotide complementary DNA substrate in the catalytic state | ELECTRON MICROSCOPY | 2.99 | 98 |
| 9 | 7S4X|1|B | Cas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformation | ELECTRON MICROSCOPY | 2.76 | 98 |
| 10 | 7Z4D|1|F | Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrate | X-RAY DIFFRACTION | 3.1 | 77 |
| 11 | 7Z4D|1|A | Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrate | X-RAY DIFFRACTION | 3.1 | 75 |
| 12 | 7S4V|1|B | Cas9 bound to 12-14MM DNA, 60 min time-point, kinked conformation | ELECTRON MICROSCOPY | 3.28 | 98 |
| 13 | 6O0Y|1|B | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.37 | 98 |
| 14 | 6O0X|1|B | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.28 | 98 |
| 15 | 6O0Z|1|B | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | ELECTRON MICROSCOPY | 3.3 | 96 |
| 16 | 4ZT9|1|B | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-RAY DIFFRACTION | 3.1 | 72 |
| 17 | 4ZT0|1|B | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-RAY DIFFRACTION | 2.9 | 72 |
| 18 | 4ZT0|1|D | Crystal structure of catalytically-active Streptococcus pyogenes Cas9 in complex with single-guide RNA at 2.9 Angstrom resolution | X-RAY DIFFRACTION | 2.9 | 72 |
| 19 | 4ZT9|1|D | Nuclease-inactive Streptococcus pyogenes Cas9 (D10A/H840A, dCas9) in complex with single-guide RNA at 3.1 Angstrom resolution | X-RAY DIFFRACTION | 3.1 | 72 |