5XJC Summary
- Structure title
- Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom
- Authors
- Release date
- 2017-07-05
- Experimental technique
- ELECTRON MICROSCOPY
- Resolution
- 3.6 Å
- Chains
- 4 RNA chains from Homo sapiens, Human mastadenovirus C
- 46 other chains
- Nucleic acid compounds
- Other compounds
- U5 snRNA, U6 snRNA, pre-mRNA, Homo sapiens small nuclear RNA (U2) gene
- Pre-mRNA-processing-splicing factor 8, 116 kDa U5 small nuclear ribonucleoprotein component, U5 small nuclear ribonucleoprotein 200 kDa helicase, U5 small nuclear ribonucleoprotein 40 kDa protein, Pre-mRNA-splicing factor SYF1, Crooked neck-like protein 1, Pre-mRNA-splicing factor SPF27, Cell division cycle 5-like protein, Pre-mRNA-splicing factor SYF2, Protein BUD31 homolog, Pre-mRNA-splicing factor RBM22, Spliceosome-associated protein CWC15 homolog, Intron-binding protein aquarius, SNW domain-containing protein 1, Peptidyl-prolyl cis-trans isomerase-like 1, Pleiotropic regulator 1, Serine/arginine repetitive matrix protein 2, Pre-mRNA-splicing factor CWC22 homolog, Pre-mRNA-processing factor 17, PRKR-interacting protein 1, ATP-dependent RNA helicase DHX8, Pre-mRNA-splicing factor SLU7, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein-associated proteins B and B', Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, Small nuclear ribonucleoprotein Sm D3, Small nuclear ribonucleoprotein-associated proteins B and B', Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, U2 small nuclear ribonucleoprotein A', U2 small nuclear ribonucleoprotein B'', Pre-mRNA-processing factor 19, Pre-mRNA-processing factor 19, Pre-mRNA-processing factor 19, Pre-mRNA-processing factor 19, Eukaryotic initiation factor 4A-III, Protein mago nashi homolog 2, RNA-binding protein 8A, Protein CASC3
Pairwise Interactions
Interactions annotated by FR3D:- 91 base-pairs
- 313 base-stacking
- 11 base-phosphate
- 10 base-ribose
- 5 oxygen stacking
- 1 sugar-ribose
RNA 3D Motifs
In the current release of the RNA 3D Motif Atlas, 5XJC contains:- 5 hairpin loops from 0 motif groups
- 19 internal loops from 0 motif groups
- 1 junction loop from 0 motif groups
3D Redundancy
5XJC has chains which belong to the following equivalence classes in the current representative set:- NR_all_73286.31 (1)
- NR_all_67830.2 (1)
- NR_4.0_73286.31 (1)
- NR_4.0_67830.2 (1)
- NR_20.0_73286.31 (1)
- NR_20.0_67830.2 (1)
Similar structures
9S2E 8I0R 8C6J 7QTT 6ZYM 8I0V 8QOZ 7DVQ 8QPB 8RC0 8I0T 6QDV 6FF4 8Q7Q 7W59 8Q91 7W5A 8Q7N 9S2F 8QP8 8I0U 8QPE 8I0P 6QX9 8RO2 8QZS 8QPA 6ICZ 9FMD 8Q7V 8QPK 8R09 8R0B 7W5B 8I0W 6ID0 6QW6 6ID1 8Q7X 8QP9 6FF7 8Q7W 8QO9 5YZG 8I0S 8CH6 7ABF 5MQF 5O9Z 7AAV 8R08 8R0A 6AHD 6AH0 8RM5 7A5P 5Z56 7ABG 7ABI 5Z58 9R8V 5Z57 8QXD 3JCR 8H6L 8H6K 8H6E 8H6J 8Y6OStructures from NR_all_73286.31